Regulation of Ribosomal Gene Transcription by C-Myc During Differentiation and Lymphomagenesis.

Grant number: 400120

Abstract

A fundamental question in medical biology revolves around how cells respond to the demands to grow and produce proteins, particularly in the setting of the rapid growth of cancer cells. One of the important facets of cellular growth is the production of new proteins needed for all areas of cell life. It is well known that cellular growth involves the production of proteins and this in turn requires the transcription or duplication of ribosomal RNAs (rRNAs). The control of rRNA synthesis, however, is not well understood. We have identified a novel process to link a cancer causing gene c-MYC to the control of protein production in cells through regulation of rRNA synthesis. Our experiments wil..

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Transcription of the ribosomal RNA genes (rDNA) by RNA polymerase I (Pol I) is a major control step for ribosome synthesis and is ..

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Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

J Quin, KT Chan, JR Devlin, DP Cameron, J Diesch, C Cullinane, J Ahern, A Khot, N Hein, AJ George, KM Hannan, G Poortinga, KE Sheppard, KK Khanna, RW Johnstone, D Drygin, GA McArthur, RB Pearson, E Sanij, RD Hannan

2016-01-01

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AKT signalling is required for ribosomal RNA synthesis and progression of Eμ-Myc B-cell lymphoma in vivo

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The dysregulation of PI3K/AKT/mTORC1 signalling and/or hyperactivation of MYC are observed in a high proportion of human cancers, ..

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2013-01-01

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AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer

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2011-08-30

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C-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol i availability during granulocyte differentiation

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2011-04-01

Loss of c-MYC is required for downregulation of ribosomal RNA (rRNA) gene (rDNA) transcription by RNA Polymerase I (Pol I) during ..

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